منابع مشابه
Dietary fat overload reprograms brown fat mitochondria
Chronic nutrient overload accelerates the onset of several aging-related diseases reducing life expectancy. Although the mechanisms by which overnutrition affects metabolic processes in many tissues are known, its role on BAT physiology is still unclear. Herein, we investigated the mitochondrial responses in BAT of female mice exposed to high fat diet (HFD) at different steps of life. Although ...
متن کاملWhither brown fat?
In 1551 Gessner described a lobular fatty tissue which we now know as brown adipose tissue (BAT). Apart from a few descriptions of the tissue in hibernators, it was then virtually ignored by scientists for the next four hundred years until its involvement in the thermoregulation of non-hibernating mammals was suggested (Smith, 1961). However, even after this work in the early 1960s, doubts over...
متن کاملBrown fat and thermogenesis.
Historical Background. ..................................................... 330 PhylogeneticDistribution .................................................. 332 AnatomyandTopology ................................................... 333 Vasculature of Brown Adipose Tissue. ...................................... 338 Microcirculation and vascularity .......................................... 338 G...
متن کاملDoes dieting make you fat?
Dieting Makes You Fat, the title of a 1980s book on weight control, is a popularised paradox, conveying a conclusion that is consistent with personal experience and the reported failure of most dietary approaches in the treatment of obesity. Few studies have been designed specifically to test this association. Yet there are prospective data showing that baseline dieting or dietary restraint inc...
متن کاملBrown fat - hotting up again.
For a decade or so from the late 1970s brown adipose tissue was a key focus of obesity research. The concept that adaptive changes in energy expenditure are important in the regulation of energy balance, with reductions in thermogenesis as a major factor in the development of obesity, had taken centre stage. This was based on some pivotal observations from studies on experimental animals. Brown...
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ژورنال
عنوان ژورنال: Science
سال: 2018
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.362.6421.1373-b